Meetings and Events

GUM Online-Workshops 2021

1st Session – Genotoxic carcinogens
15.03.2020, 10 a.m. - 1 p.m. (CET)

Keynote speakers:

Andrea Hartwig (Karlsruhe Institute of Technology, Karlsruhe, GER)
Mode of action-based risk assessment of genotoxic carcinogens – results of a MAK/SKLM working group

Melanie Esselen (University of Münster, Münster, GER)
Natural genotoxins in food and food products – a challenge for risk assessment

Margherita Bignami (EFSA, Parma, ITA)
Genotoxic carcinogens as food contaminants: role of the mode of action in risk assessment

2nd Session – Advanced in vitro models
18.03.2020, 3 - 6 p.m. (CET)

Keynote speakers:

Barbara Rothen-Rutishauser (Adolphe Merkle Institute – Fribourg, CH)
Predictive lung tissue models to assess the hazard of aerosols

Thomas Hartung (Johns Hopkins Bloomberg School of Public Health, Baltimore, USA)
Advancing cell culture from microphysiological to micropathopysiological systems

Stefan Pfuhler (Procter & Gamble, Cincinnati, USA)
Non-animal models that can be used to follow-up on positive results from the standard genotoxicity testing battery – an overview of recent progress of the Cosmetics Europe program


Selected from Abstract

Giovanna Ranzini, Franziska Ebert, Sandra-Marie Müller ,Stefanie Raschke, Barbara Hertel, Michael Stiboller, Julia Bornhorst, Tanja Schwerdtle (University of Potsdam)

Parallel analysis of transfer and neurodegeneration in a 3D blood-brain barrier model


Awadhesh N. Jha (University of Plymouth, UK)

“virtual fish”: Liver, Intestinal and gill organoids as an in vitro alternatives to live fish studies


Stefanie Raschke, Barbara Witt, Franziska Ebert, Tanja Schwerdtle (University of Potsdam)

Cu/Se combination study in Se-suboptimal supplied astrocytes


Vivien Michaelis, Leonie Aengenheister, Tanja Schwerdtle, Tina Buerki-Thurnherr, Julia Bornhorst (University of Wuppertal)

Modeling maternal-fetal transfer using a 3D in vitro model of human villous trophoblasts


Naveed Honarvar, David Manuel Schuster, Alina Göpfert, Claudia Rülker, Caroline Gomes and Robert Landsiedel (BASF SE, Ludwigshafen)

Establishment of an in vitro transgenic rodent (TGR) assay for detection of potential mutagens

3rd Session – Industrial Genotoxicity (Organized by the new GUM-IGG)
25.03.2020, 3-6 p.m. (CET)


Lea A. l. Vaas (Bayer AG, Berlin, GER), Andreas Zeller (F. Hoffmann – La Roche Ltd, Basel, CH)
Statistical evaluation of the flow cytometric micronucleus in vitro test – same but different

Birgit Mertens (Sciensano, Brussels, BE) & Paul White (Health Canada, Ottawa, CA)
An update on the OECD assessment of miniaturized Ames assays

Giel Hendriks (Leiden University Medical Centre, Leiden, NL) & Steven Bryce (Litron Laboratories, New York City, USA), Ulrike Hemmann (Sanofi, Frankfurt, GER)
ToxTracker/Multiflow: An update on mechanistic/screening assays and their applications

Roland Froetschl (Federal Institute for Drugs and Medical Devices, Bonn, GER) & Andreas Czich (Sanofi, Frankfurt, GER)
N-nitroso impurities in sartans and other drugs

Carol Beevers (Exponent Inc.) & Jasmin Lott (Boehringer Ingelheim)
Consideration of Criteria used for Dose Selection and defining the MTD for in vivo Follow Up Studies: Impact and Regulatory Acceptance

The event is free of charge and GUM members as well as non-members are kindly invited to join. In case you want to register please contact Julia Bornhorst ( in order to receive the registration form. Registration is possible until 26 of February.