33rd GUM Meeting (Würzburg, October 5th – 7th 2022)

Dear colleagues, dear friends,

It is a great pleasure to welcome you to Würzburg for the 33rd GUM Meeting (October 5th – 7th 2022). Würzburg is located in Franconia in the northern part of Bavaria. The city’s main landmark, the “Residenz”, was completely rebuilt after being damaged to a large extend in the second world war, and is now listed as UNESCO world heritage. Other highlights of the city include the Festung Marienberg and the Alte Mainbrücke.

The venue for this conference will be the University of Würzburg which is one of the largest universities in Germany with about 29,000 students. The University of Würzburg was already founded in 1402, making it the fourth oldest university in Germany and the first in Bavaria. Many eminent scholars and scientists, including 14 Nobel Laureates, have conducted research and taught in Würzburg. To provide a structured PhD program, the Graduate School of Life Sciences (GSLS) was founded by the German Excellence Initiative in 2006. Since then, more than 500 students have graduated from the GSLS, and more than one third of them were international students.

The ten faculties of our university are spread throughout the city, and the conference will be held in the Institute of Pharmacology and Toxicology, which is located in the area of the University Hospital. This is the second time after 2004 for our institute to host a GUM meeting. We are looking forward to exciting presentations. Genomic stability and DNA repair, hormone mediated DNA damage, nutrition and carcinogenesis, risk assessment of botanicals, and updates on regulatory issues are the main topics of this meeting. The contribution of young scientists is very important to us, which is emphasized by a dedicated young scientist session. Furthermore, the GUM Award as well at the GUM Young Scientist Award are presented during the conference. Additonally, oral presentations and posters will be awarded.

After 2.5 years of online conferences, the 33rd GUM Meeting will be held again as in-person conference.  We are excited to return to a face-to-face exchange of ideas and scientific discussions and we wish you a stimulating and enjoyable meeting.

Jörg Fahrer and Helga Stopper

On behalf of the scientific and local organizing committee:

Jörg Fahrer, Nicole Schupp, Kristina Trenz, Franziska Ebert, Volker Arlt, Naveed Honarvar, Stefan Pfuhler, Ezgi Eylül Bankoglu, Helga Stopper

Registration fee full GUM members: 350 €
Registration fee non-GUM members: 400 €
Registration fee students: 175 €

Online registration deadline August 31st

– COVID-19 regulations that are in force at the time of the conference will have to be considered

You can submit an abstract after you register for the conference or by using the link below.

  • Deadline for abstract submission is 1st August

You will be informed of you abstract acceptance by mid August

Abstract title: maximum of 25 words
Maximum 300 words – no images
Maximum of 20 authors / institutions

Conference Schedule

Tuesday 4th October

1:00 – 5:00pmYoung Scientist Workshop
6:30pmWelcome Reception at Historisches Welz-Haus der Universität“, Klinikstr. 6, Würzburg

Wednesday 5th October

08:00 – 09:00amRegistration
08:45 - 09:00Welcome Address
09:00 - 12:30pmSession 1 – Genomic Stability and DNA repair
09:00 - 09:30amVilhelm Bohr (Baltimore, USA) DNA damage and mitochondrial dysfunction in neurodegeneration and aging
09:30 - 10:00amAswin Mangerich (Konstanz, Germany) It takes two to tango: On the reciprocal relationship of PARP1 and XRCC1 in genotoxic stress response
10:00 - 10:30amIllio Vitale (Turin, Italy) Replication stress and mitosis deregulation in colorectal cancer stem cells
10:30 – 11:00amCoffee Break
11:00 – 11:30 am Zuzana Storchova (Kaiserslautern, Germany) Modeling aneuploidy and chromosomal instability to understand cancer development and drug response
11:30 – 11:45 amThomas Hofmann (Mainz, Germany) Novel insight into DNA double-strand break repair
11:45 – 12:00 amMarkus Christmann (Mainz, Germany) p21-dependent CDK4 silencing and activation of the DREAM complex is sufficient to mediate B[a]P and IR-induced cellular senescence
12:00 – 12:15pmLeen Sarmini - Size determinants for human nucleotide excision repair of N2-alkylguanine modifications
12:15 - 12:30pmStella Marie Reamon-Buettner - Malignant peritoneal mesotheliomas in rats induced by multiwalled carbon nanotubes and amosite asbestos: transcriptome and epigenetic profiles
12:30 – 1:30pmLunch Break
1:30pm - 4:30pmSession 2 – Hormone mediated DNA damage and carcinogenesis
1:30 – 2:00pmMelanie Flint (Brighton, UK) The role of stress and glucocorticoids on cancer risk
2:00 – 2:30pmEylül Bankoglu (Würzburg, Germany) Obesity and Cancer Risk: the role of insulin
2:30 – 3:00 pmNicole Schupp (Düsseldorf, Germany) Blood pressure regulating hormones cause oxidative stress, DNA damage and increase mutations
3:00 – 3:30pmCoffee Break
3:30 – 4:00pmLeane Lehmann (Würzburg, Germany) Role of estrogens in the etiology of female breast cancer: current knowledge and open questions
4:00 - 4:30pmStatistical Issues - Short Talks
4:00 – 4:15pmMax Menssen - The evaluation of an actual control group based on historical control data
4:15 - 4:30pmTimur Tug - In vivo alkaline comet assay data analyses using negative and positive controls – Results from the GUM Working Group “Statistics”
4:30 – 5:45pmPoster Session 1
5:45 – 7:00pmGeneral Assembly of the GUM

Thursday 6th October

08:30 – 9:15amGUM Award lecture
09:15 – 12:30pmSession 3 – Nutrition and carcinogenesis
09:15 – 9:45amAngela Mally (Würzburg, Germany) Is there a role for replication stress in Ochratoxin A genotoxicity?
09:45 – 10:15 amGe Lin (Hongkong, China) Mechanism-based biomarkers for experimental, diagnostic and clinical risk study on pyrrolizidine alkaloids exposure
10:15 – 10:45amCoffee Break
10:45 – 11:15 amShana Sturla (Zurich, Switzerland) The formation and fate of DNA adducts from dietary carcinogens
11:15 – 11:45 amJörg Fahrer (Kaiserslautern, Germany) Mechanisms of intestinal carcinogenesis triggered by dietary factors and impact of DNA repair
11:45 - 12:15Andriy Khobta (Jena, Germany) Revealing hidden details of genotoxicity pathways with synthetic DNA lesions
12:15 – 12:30 pmTina Kostka - Nitrosylation of the red meat compound heme does not increase its genotoxic, mutagenic and cell transforming potential
12.30 – 1:30pmLunch Break
1:30 - 3:00pmSession 4 – Young Scientist Session sponsored by SCC Scientific Consulting Company
1:30 - 2:00pmGUM Young Scientist Award Lecture
2:00 - 2:15pmMax Carlsson - Role of nucleotide excision repair in methyleugenol-derived DNA damage and apoptotic cell death
2:15 - 2:30pmMartin Link - Impact of cadmium compounds on the protein composition in BEAS-2B cells
2:30 - 2:45pmManuel Haas - Potency ranking of structurally diverse pyrrolizidine alkaloids using an in vitro genotoxicity test battery in human hepatocytes and impact of OCT1-mediated uptake
2:45 - 3:00pmMboni Johnston - hiPSCs and hiPSCs-derived renal proximal tubular cells showed different response to nephrotoxic compounds
3:00 – 4:15pmCoffee Break + Poster Session 2
4:15 - 5:45pmSession 5 – iGUM & GUM - The HESI Botanical Safety Consortium’s genotoxicity testing framework – Various perspectives
4:15 – 4:40 pmAuthorities: Kristine Witt (Washington, USA)
4:40 - 5:05Science: Helga Stopper (Würzburg, Germany)
5:05 - 5:30pmIndustry: Stefan Pfuhler (Cincinnatti, USA)
5:30 - 5:45Questions and Discussion
7:00pm Visit wine cellar

Friday 7th October

08:30 – 12:40pmSession 6 – iGUM – current issues with relevance to industry
08:30 – 09:30amFrancesco Marchetti (Ottawa, Canada) Advanced technologies for chemical safety assessment: toward reduction and replacement of conventional rodent mutagenicity tests.
09:30 – 10:10am IWGT Wrap up – Hansjoerg Martus (Basel, Switzerland) Summaries from 2022 IWGT in Ottawa, Canada
10:10 –10:50amCoffee Break- “Coffee with the industry”
10:50 – 11:30amPatricia Escobar (Lansdale, USA) Genotoxicity Assessment of Molnupiravir
11:30 – 12:10pmRoland Frötschl (Bonn, Germany) Current considerations for In vitro follow up options of an In vitro positive in standard genetic toxicity tests
12:10 - 12:25pmAlina Göpfert - Characterization of substance induced mutations in the in vitro Transgenic Rodent (TGR) assay
12:25 - 12:40pmNaveed Honovar - Assessment of the Mutagenic Potential of a Protoporphyrinogen-Oxidase Inhibitor Herbicide
12:40 – 12:50pmAwarding of best oral presentations and posters
12:50 – 1:00pmClosing remarks and Farewell


We can offer special rates for a contingent of rooms in two hotels. They are well connected to the conference venue by bus and are close to the city center.

GHOTEL Hotel & Living Würzburg

From Ghotel you can easily reach the conference venue by bus number 12 and 21. It is only 2 bus stops away. The bus stop just across the street from Ghotel is called “Schweinfurter Straße”.

You can book your stay until 19th of August 2022 via e-mail (wuerzburg@ghotel.de) or a phone call (0049 931 359 620). Please do not forget to write or mention the reference word “GUM2022”!

Price per night: 89 Euro for a single room including breakfast

Hotel Amberger

From Hotel Amberger you can easily reach the conference venue by bus number 12. It is 4 bus stops away. The bus stop approx. 180 m away from Hotel Amberger, across the street, is called  “Mainfranken Theater”. The next closest bus stop “Schweinfurter Straße”, is within 10 min walking distance and is connected by bus number 21 in addition to bus number 12.

You can book your stay until 20th of August 2022 via e-mail (reservation@hotel-amberger.de) or a phone call (0049 931 35100). Please do not forget to write or mention the reference word “GUM2022”!

Price per night: 104.50 Euro for a single room including breakfast, without breakfast 95.00 Euro.



The conference venue is located at the Institute of Pharmacology and Toxicology, Versbacher Straße 9, 97078, Würzburg, Germany. The bus stop is “Neumühle”, which can be reached with bus number 12 and 21, and is about 100 m from the venue. For ticket information see the travel tab above. There is no available parking space at the institute and also no parking in the surrounding streets, so please use public transportation to the venue. A taxi ride (Taxi Würzburg: +49 931-19410) from the main train station (or Ghotel) costs approx. 10 Euro.


How to reach to the conference venue

Frankfurt Airport

Distance to venue: 125 km

Travel time by public transport (train directly from the airport): 120 min

Albrecht Dürer Airport Nürnberg

Distance to venue: 117 km

Travel time by public transport (subway from the airport to main train station Nürnberg, then train to Würzburg): 120 min

Public transportation

Würzburg has busses and trams. The conference venue can be reached by bus number 12 and 21, for example from the main train station. Tickets can be bought on the bus or at some bus stations equipped with ticket machines. Single ride tickets cost 2.60 Euro. A multiple ticket for 6 rides costs 10.80 Euro and it can also be used by up to 6 people going together. Short distance tickets (“Kurzstrecke”, up to 4 stops after entering) cost 1.40 Euro. From Ghotel and Hotel Amberger, short distance tickets are sufficient. A one-day ticket costs 4.40 Euro, a “day ticket plus” 6.20 Euro and can be used by 2 people riding together.

Conference Dinner

The conference dinner will be held on Thursday the 6th of October, at Bürgerspital. The costs for this event are included in your conference fee.

Please specify your dietary requirements/preferences during registration.

The meeting is supported by

And there is still the option to support the GUM meeting 2022.
As you can imagine, it is impossible to organize such a conference without external funding. We therefore hope that you will support the GUM by becoming a Member, Meeting Sponsor, Exhibitor, or Advertiser.
In return for a meeting sponsorship, we will offer to acknowledge your contribution in the program booklet and, if desired, include a flyer in the congress bag.

For exhibitors, we offer the rental of an approx. 3 m x 2 m space in the exhibition area at a price of 750 € for the duration of the meeting, including a free registration.
If you would like to advertise, we offer a full-page ad in the program booklet for 350 € for a full page and a half-page ad for 200 €. For 200 € you can include a flyer in the conference bag.
Note that flyers need to be provided and shipped to the conference venue at your expense.

The GUM Award, an honour for senior scientists who made outstanding contributions in the field of mutation and cancer research and the GUM Young Scientist Award, that honours young scientists for outstanding contributions in the field of mutation and cancer research, are granted during the conference. The awardees are invited to give an award lecture at the conference.

GUM offers young members financial support for the participation in meetings organized by GUM or EEMGS in form of travel grants and/or reduced conference fees. In selected cases GUM also provides financial support for other conferences linked to GUM interests.

More details can be found here